Multiple myeloma (MM) is a malignant immunoproliferative disease involving plasma cells, leading to their malignant proliferation and the production of monoclonal paraproteins.Intracranial tumor spread in Console Interface MM is very rare.This is a unique and infrequent localization, which makes it difficult to diagnose the disease.We report a rare
Abstract Background Dasatinib (Sprycel) was developed as a tyrosine kinase inhibitor targeting Bcr-Abl and the family of Src kinases.Dasatinib is commonly used for the treatment of acute lymphoblastic and chronic myelogenous leukemia.Previous clinical studies in melanoma returned inconclusive results and suggested that patients respond highly heter
The two-component system (TCS) is a significant signal transduction system for bacteria to adapt to complicated and variable environments, and thus has recently been regarded as a novel target for developing antibacterial Dog Pack agents.The natural product luteolin (Lut) can inhibit the autophosphorylation activity of the typical histidine kinase
Abstract Background Most proteins function by interacting with other molecules.Their interaction interfaces are highly conserved throughout evolution to avoid undesirable interactions that lead to fatal disorders in Acetaminophen cells.Rational drug discovery includes computational methods to identify the interaction sites of lead compounds to the